Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures

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Hyperthermic seizures and hyperthermia in immature rats modify the subsequent pentylenetetrazole-induced seizures

It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood. However, latency period between febrile seizure and the onset of the first spontaneous seizure has not been evaluated. The present study was designed to investigate the susceptibility to subsequent seizures in immature rats that had experienced early-life hyperthermi...

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Arsenic and Oxidative Stress in Pentylenetetrazole-induced Seizures in Mice

Background and Objective: Chronic arsenic toxicity is a widespread problem; the role of brain oxidative stress has been suggested in the genesis of epilepsy and in the post-seizure neuronal death. However, studies investigating the effects of arsenic on seizure and related mechanisms are limited. The purpose of this study was to examine the effect of prolonged exposure to sodium arsenite on oxi...

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Hyperthermia-Induced Febrile Seizures Have Moderate and Transient Effects on Spatial Learning in Immature Rats

The aim of this study was to characterize a novel animal model hyperthermia-induced febrile seizure and to investigate the impacts of repetitive febrile seizures on spatial learning and memory performances in immature rats. Methods. Rats were subjected to hyperthermia exposure one, two, or three times in 10-day intervals during 30 min in a water bath warmed at 45-50°C and their behaviour was mo...

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Decrease of hippocampal GABA B receptor-mediated inhibition after hyperthermia-induced seizures in immature rats.

PURPOSE Whether febrile seizures have detrimental consequences on the brain is still controversial. We hypothesized that neuronal inhibition in the hippocampus is altered after hyperthermia-induced seizures in immature rats. METHODS Rats were given a single seizure by a heat lamp on postnatal day (PND) 15, or repeated seizures by heated air on PND 13 to 15. Fourteen or 30 days after the seizu...

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ژورنال

عنوان ژورنال: Seizure

سال: 2009

ISSN: 1059-1311

DOI: 10.1016/j.seizure.2009.04.011